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Related post: patient care rounds on general Forzest Ranbaxy medicine, infectious diseases, and immunology patients. An
attending rotation at Howard University will continue to be offered to NIAID staff members
in FY 93. Howard University has sent one fellow for a month-long rotation on NIAID's
inpatient service and is making plans for sending others in the coming medical academic year.
Clinical Accomplishments during FY 92
Clinical research proceeded along fronts of prophylaxis and immunotherapy within the
intramural clinical program. This included completion of a placebo-controlled trial of a
herpesvirus vaccine that is currently in analysis. A candidate HIV vaccine, recombinant
gpl60, that had been studied in Phase I trials here over the past several years, was used to
immunize donors in a syngeneic Forzest 20 Mg bone marrow transplant study using discordant HIV+/HIV-
twin Forzest Online pairs. Active immunotherapy with studies of gpl60 and p24 immunogens were
continued. In another trial piloting immune reconstitution in HIV infection, a nef-specific
cytotoxic T cell clone was administered to Forzest 20mg its donor with good tolerance and demonstration of
modest anti-HIV activity.
A vaccine for Crvptococcus neoformans has been shown to be immunogenic in a Phase I
trial. Studies wUl be expanded to an HTV positive population in the coming year. Alpha
interferon continues to be studied as an immune-based therapy for HTV infection, and has
been piloted in the treatment of mastocytosis, as well. Gamma interferon, after being FDA-
approved in 1991 for use in chronic granulomatous disease, entered phase IV testing to
substantiate its long term effects on phagocytic cells and the inflammatory process. In
addition, gamma interferon is being studied for its potential to enhance host defense in
patients with a newly identified X-linked susceptibility to Mycobacterium avium intracellulare
and for patients with Hyper-IgE-recurrent infection syndrome.
Therapeutic studies were aimed at a variety of disorders. Acyclovir was proven to suppress
frequentiy recurring oral herpes. FIAU demonstrated Ranbaxy Forzest efficacy in suppressing chronic hepatitis
B infection in HIV-infected patients and further studies are underway in immunocompetent
hosts. Three new anti-retroviral drugs were studied: a non-nucleoside analogue reverse
transcriptase inhibitor, L697,661; an immunotoxin, CD4-PE; and N-acetylcysteine (NAC), a
drug which may modify in vivo replication of HIV-1. BW566C80 was shown to be an
effective therapy for Pneumocystis carinii p neumonia and cerebral toxoplasmosis. A trial of
BW566C80 as treatment for cryptosporidiosis and microsporidiosis has been completed and is
in analysis. Foscamet was shown to confer a survival benefit in a group of AIDS patients
who received it as therapy for cytomegalovirus retinitis. New studies are underway to look
1 -24
at treatment of Wegener's granulomatosis and Takayasu's arteritis with low-dose methotrexate
and glucocorticoids, which were prompted by observations of high relapse rates and long-term
toxicities after treatment with glucocorticoids alone. Patients with filarial diseases and
leishmaniasis (including veterans of Desert Storm), were referred for evaluation, treatment,
and to provide research material for studies on the pathogenesis of parasitic diseases.
Observational studies conducted within the program continue to add to the body of knowledge
of a variety of disorders. Chronic fatigue syndrome is being studied from
neuroendocrinologic, immunologic, and neuropsychiatric angles. A new clinical syndrome
manifested by fatigue and lymphadenopathy and Forzest 10mg characterized by expansion of a T cell
population lacking CD4 and CDS markers, was described. A recentiy described clinical
entity involving CD4 lymphopenia and opportunistic infections in HTV seronegative
individuals has just begun to be studied.
1 -25
Animal Care Branch
Annual Report FY 92
Table of Contents
Summary.
ANIMAL CARE BRANCH
1992 Annual Report
Summary
Much of the current research in the understanding and treatment of allergies and
infectious Buy Forzest diseases requires the use of laboratory animals. The care and treatment Forzest 20 of these
animals can have a profound affect on experimental results. An animal's environment, its daily
care, the presence or absence of disease-causing microorganisms, the amount of pain or distress
that an animal experiences may affect the validity of research data generated through the use
of animals. The NIAID intramural scientists today are very sensitive to these factors and their
ethical responsibility for ensuring that animals used in research receive high quality care. All
NIAID scientists conducting research that involves animals are required to attend the NIH
course on "Using Animals in Intramural Research: Guidelines for Investigators." This course
offers not only a broad perspective on current animal issues, but also provides specific
information on actual techniques and procedures.
It is the responsibility of the NIAID Animal Care Branch to provide daily care to all
animals maintained within the NIAID animal facilities in Bethesda, Maryland, to oversee
NIAID's intramural contracts involving animals, and to assist NIAID scientists with animal-
related problems. The NIAID maintains five animal facilities at the NIH campus in Bethesda,
Maryland; one animal facility in Rockville, Maryland; two animal facilities at the Forzest India Frederick
Cancer Research Development Center in Frederick, Maryland; and foiu: animal facilities at
Rocky Movmtain Laboratories in Hamilton, Montana. Approximately 58,000 square feet of space
(26,000 sq. ft. at the NIH in Bethesda, MD; 2,500 sq. ft. at the FCRDC in Frederick, MD; and
29,000 sq. ft. in Hamilton, MT), excluding pasture land, are devoted to the NIAID Animal Care
Program.
The NIAID's Animal Care Branch provides guidance to the Institute's intramural
scientists using animals in research projects. This guidance includes assistance in the purchase
of animals, the selection and proper administration of anesthetics and analgesics, the diagnosis,
treatment and control of infectious agents, and the performance of technical procedures in
laboratory animals. The Branch maintains production colonies of over sixty different strains
of mice, hamsters, cotton rats, and rabbits for NIAID investigators within DIR or contract
animal facilities. Many of these animals are unavailable anywhere else in the world or are
available only after long delays. The NIAID Division of Intramural Research is committed to
the use of animals only when alternative methods are unavailable, and fully supports existing
Federal rules and regulations pertaining to the care and use of animals in biomedical research.
The Institute has four full-time veterinarians to help manage its' animal care and use program
and has spent, in FY91, over $1,000,000 to upgrade its' animal facilities.
ADMINISTRATIVE MANAGEMENT BRANCH
ANNUAL REPORT FY 1992
TABLE OF CONTENTS
Introduction 3-1
Personnel 3-1
Budget and Financial Management 3-1
Renovations and Space Relocations 3-2
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